Top 10 manufacturer company Chlordiazepoxide and Clidinium Bromide

		Each Libtrax capsule contains 5 mg chlordiazepoxide hydrochloride 2.5 mg clidinium bromide Each capsule also contains corn starch, lactose and talc. Gelatin capsule shells may contain methyl and propyl parabens and potassium sorbate. Chlordiazepoxide hydrochloride is a versatile, therapeutic agent of proven value for the relief of anxiety and tension. It is indicated when anxiety, tension or apprehension are significant components of the clinical profile. It is among the safer of the effective psychopharmacologic compounds. USES This medication is used along with medications that treat stomach ulcers. This combination product contains 2 medicines, chlordiazepoxide and clidinium. Chlordiazepoxide belongs to a class of drugs known as benzodiazepine anxiolytics. It works by relieving anxiety. Clidinium belongs to a class of drugs known as anticholinergics. It may help symptoms of cramping and abdominal/stomach pain by decreasing stomach acid, and slowing the intestines. DOSAGE AND ADMINISTRATION Because of the varied individual responses to tranquilizers and anticholinergics, the optimum dosage of Libtrax varies with the diagnosis and response of the individual patient. The dosage, therefore, should be individualized for maximum beneficial effects. The usual maintenance dose is 1 or 2 capsules, 3 or 4 times a day administered before meals and at bedtime. Geriatric Dosing Dosage should be limited to the smallest effective amount to preclude the development of ataxia, oversedation or confusion. The initial dose should not exceed 2 Libtrax capsules per day, to be increased gradually as needed and tolerated. WARNINGS As in the case of other preparations containing CNS-acting drugs, patients receiving Libtrax should be cautioned about possible combined effects with alcohol and other CNS depressants. For the same reason, they should be cautioned against hazardous occupations requiring complete mental alertness such as operating machinery or driving a motor vehicle. CONTRAINDICATIONS Libtrax is contraindicated in the presence of glaucoma (since the anticholinergic component may produce some degree of mydriasis) and in patients with prostatic hypertrophy and benign bladder neck obstruction. It is contraindicated in patients with known hypersensitivity to chlordiazepoxide hydrochloride and/or clidinium bromide. PATIENT INFORMATION To assure the safe and effective use of benzodiazepines, patients should be informed that, since benzodiazepines may produce psychological and physical dependence, it is advisable that they consult with their physician before either increasing the dose or abruptly discontinuing this drug. SIDE EFFECTS Drowsiness, blurred vision, dry mouth, dry eyes, constipation, or increased heartbeat may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly. To relieve dry mouth, suck on hard candy or ice chips, chew gum, drink water, or use a saliva substitute. To prevent constipation, maintain a diet adequate in fiber, and drink plenty of water. If you become constipated while using this drug, consult your pharmacist for help in selecting a laxative (e.g., stimulant-type with stool softener). Presentation Libtrax Strip pack of 10 Capsules

The combination of chlordiazepoxide and clidinium bromide is used to treat ulcers and irritable bowel syndrome. It helps relieve stomach spasms and abdominal cramps.
This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information.
The combination of chlordiazepoxide and clidinium bromide comes as a capsule to be taken by mouth. It usually is taken three or four times a day, before meals and at bedtime. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take chlordiazepoxide and clidinium bromide exactly as directed.
Chlordiazepoxide can be habit-forming. Therefore, when taking chlordiazepoxide and clidinium bromide, do not take a larger dose, take it more often, or for a longer time than your doctor tells you to. Tolerance may develop with long-term or excessive use, making this medication less effective. This medication must be taken regularly to be effective. Do not skip doses even if you feel that you do not need them. Do not take chlordiazepoxide and clidinium bromide for more than 4 months or stop taking this medication without talking to your doctor. Stopping the drug suddenly can worsen your condition and cause withdrawal symptoms (anxiousness, sleeplessness, and irritability). Your doctor probably will decrease your dose gradually.
GENERIC NAME: chlordiazepoxide hydrochloride and clidinium bromide
BRAND NAME: Librax
DRUG CLASS AND MECHANISM: Librax combines the antianxiety action of librium (chlordiazepoxide) and the antispasmodic effects of clidinium. It also blocks the acid secretion of the gastrointestinal tract and inhibits blocking the action of nerves that are very active in certain diseases.
PRESCRIPTION: yes
GENERIC AVAILABLE: yes

PREPARATIONS: Capsules: 5mg chlordiazepoxide hydrochloride and 2.5mg clidinium bromide.
STORAGE: Capsules should be stored at room temperature in a tightly close container.
Librax combines in a single capsule formulation the antianxiety action of chlordiazepoxide hydrochloride and the anticholinergic/spasmolytic effects of clidinium bromide, both exclusive developments of Roche research.
Each Librax capsule contains 5 mg chlordiazepoxide hydrochloride and 2.5 mg clidinium bromide. Each capsule also contains corn starch, lactose and talc. Gelatin capsule shells may contain methyl and propyl parabens and potassium sorbate, with the following dye systems: D&C Yellow No. 10 and either FD&C Blue No. 1 or FD&C Green No. 3.
Chlordiazepoxide hydrochloride is a versatile, therapeutic agent of proven value for the relief of anxiety and tension. It is indicated when anxiety, tension or apprehension are significant components of the clinical profile. It is among the safer of the effective psychopharmacologic compounds.
Chlordiazepoxide hydrochloride is 7-chloro-2-methylamino-5-phenyl-3H-1,4-benzodiazepine 4-oxide hydrochloride. A colorless, crystalline substance, it is soluble in water.
Special Instruction :

1. This medication can cause drowsiness and blurred vision. Do not drive a car or operate dangerous maochinery until you know how it affects you.
2. Because chlordiazepoxide can be habit-forming, do not take more of it, do not take it more often, and do not take it for a longer time than as directed.
3. Do not stop taking this drug without consulting your doctor, especially if you have been taking it for a long time.
4. Stopping the drug abruptly can cause withdrawal symptoms.
5. Your doctor may want to decrease your dose gradually. Keep all appointments with your doctor and the laboratory.

Side Effects :

1. Eye sensitivity to light. Wear sunglasses when exposed to brigh light.
2. Dry mouth. Suck sugarless hard candies, drink fluids, or chew sugarless gum.
3. Drowsiness, dizziness, faintness, weakness, confusion, fatigue, muscle incoordination. If these effects persist for more than a few days, contact your doctor.
4. Difficulty urinating, constipation, blurred vision, fast heartbeat, palpitations, excitement, talkativeness, restlessness, anxiety, sleeping problems, trembling, muscle spasms. Stop taking the drug and contact your doctor.

Other Precautions :

1. Women who are pregnant or breast-feeding should inform their doctors.
2. If you become pregnant while taking this drug, notify your doctor promptly. Before you take this drug, tell your doctor what prescription and nonprescription drugs you are taking, especially digoxin, ketoconazole, levodopa, antacids, cimetidine, disulfiram, seizure medication, sleeping pills, prescription pain medication, medication for depression, barbiturates, tranquilizers, sedatives, antihistamines, and medication for allergies and colds.
3. Do not drink alcoholic beverages. Alcohol adds to the drowsiness caused by this medication.
4. Do not smoke. Smoking can decrease this medication's effectiveness.
5. If you have liver disease, kidney disease, thyroid problems, high blood pressure, heart disease, or glaucoma, tell your doctor before taking this medication.
6. Do not allow anyone else to take this medication.
Chlordiazepoxide + Clidinium
It is Generic for Librax, (Chlordiazepoxide HCl + Clidinium HBr). It's Strength is 5mg/2.5mg. It is a combination of a benzodiazepine called Chlordiazepoxide Hydrochloride, similar to (Xanax or Valium), but also contains an anticholinergic Clidinium Hydrobromide which is used for stomach ulcers, ...

Chlordiazepoxide and Clidinium Bromide
Librax


... CHLORDIAZEPOXIDE; CLIDINIUM is a combination of medicines that helps to relax your stomach and bowel. It may help to relieve spasms and decrease stomach acid. It may help to treat peptic ulcer disease or irritable bowel syndrome. Generic chlordiazepoxide; clidinium capsules are available. ...
Drug Digest - more...

Chlordiazepoxide Systematic (IUPAC) name 9-chloro-5-hydroxy-N-methyl-6-phenyl- 2,5-diazabicyclo[5.4.0]undeca- 1,6,8,10-tetraen-3-imine Identifiers CAS number 58-25-3 ATC code N05BA02 PubChem 2712 DrugBank APRD00682 Chemical data Formula C16H14ClN3O Mol. weight 299.8 Pharmacokinetic data Bioavailability ? Metabolism Hepatic Half life 5-25 hours Excretion Renal Therapeutic considerations Pregnancy cat. D (USA) Legal status Schedule IV(US)


Simultaneous determination of chlordiazepoxide and clidinium bromide in pharmaceutical formulations by derivative spectrophotometry

M. Inés Toral , Pablo Richter, Nelson Lara, Pablo Jaque, Cesar Soto and Marcela Saavedra
Department of Chemistry, Faculty of Sciences, University of Chile, P.O. Box 653, Santiago, Chile

Received 4 January 1999;
revised 9 July 1999;
accepted 9 July 1999.
Available online 11 October 1999.

Abstract
A direct and simple first derivative spectrophotometric method has been developed for the simultaneous determination of clidinium bromide and chlordiazepoxide in pharmaceutical formulations. Acetonitrile was used as solvent for extracting the drugs from the formulations and subsequently the samples were evaluated directly by derivative spectrophotometry. Simultaneous determination of the drugs can be carried out using the zero-crossing method for clidinium bromide at 220.8 nm and the graphical method for chlordiazepoxide at 283.6 nm. The calibration graphs were linear in the ranges from 0.983 to 21.62 mg/l of clidinium bromide and from 0.740 to 12.0 mg/l of chlordiazepoxide. The ingredients commonly found in commercial pharmaceutical formulations do not interfere. The proposed method was applied to the determination of these drugs in tablets.
Author Keywords: Chlordiazepoxide; Clidinium bromide; Simultaneous determination; First derivative spectrophotometry; Pharmaceutical formulations
Article Outline
1. Introduction
2. Materials and methods
2.1. Instruments
2.2. Reagents
2.3. Calibration procedure for determination of I and II in mixtures
2.4. Procedure for determination of I and II in tablets
3. Results and discussion
3.1. pKa Determination
3.2. Spectral features
3.3. Selection of spectral variables
3.3.1. Derivative order
3.3.2. Selection of the analytical wavelengths
3.3.3. Selection of Δλ value
3.4. Analytical features
3.5. Application
4. Conclusion
Acknowledgements
References

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Reason for the drug Drug Duration
Crohn's Disease Mesalamine n/a
Crohn's Disease Mercaptopurine n/a
Not Specified Prednisone Tab n/a
Not Specified Chlordiazepoxide n/a
Not Specified Clidinium Bromide n/a

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196 related reports are studied for females and males at all ages when co-using Mesalamine, Mercaptopurine, Prednisone Tab, Chlordiazepoxide, Clidinium Bromide:
Comparison with the patient's adverse outcomes:
Name Count (% of total reports)
Alanine Aminotransferase Increased 11 (5.61%)
Aspartate Aminotransferase Increased 12 (6.12%)
Blood Bilirubin Increased 9 (4.59%)
Blood Lactate Dehydrogenase Increased 4 (2.04%)
Drug Toxicity 4 (2.55%)
Enzyme Abnormality 2 (1.02%)
Fatigue 18 (10.20%)
Haemoglobin Decreased 10 (5.10%)
Nausea 17 (8.67%)
Palmar-plantar Erythrodysaesthesia Syndrome 7 (3.57%)